Pancreatic cancer is a serious and often deadly disease that affects the pancreas, a gland located behind the stomach that plays a key role in digestion and blood sugar regulation. Recent research has also found an association between pancreatic cancer and depression, suggesting that individuals with pancreatic cancer may be at increased risk for developing this mental health condition. One study, published in the Journal of the National Cancer Institute, found that individuals with pancreatic cancer had a higher risk of developing depression than those without the disease. The study, which included over 1,000 individuals with pancreatic cancer and a control group of over 3,000 individuals without the disease, found that those with pancreatic cancer were more than twice as likely to develop depression. Other studies have also found a similar association between pancreatic cancer and depression. For example, a study published in the Journal of Clinical Oncology found that individuals with pancreatic cancer had significantly higher levels of depression compared to those without the disease. Additionally, a study published in the Journal of Pain and Symptom Management found that individuals with pancreatic cancer had higher levels of depression and anxiety compared to those with other types of cancer. The exact mechanisms behind the association between pancreatic cancer and depression are not fully understood. However, researchers believe that the physical and emotional stress of living with a serious illness, as well as the side effects of cancer treatment, may contribute to the development of depression. Additionally, pancreatic cancer can often go undetected until it is in an advanced stage, which can lead to feelings of hopelessness and despair. It is important for healthcare professionals to be aware of the association between pancreatic cancer and depression and to screen for depression in individuals with pancreatic cancer. Early detection and treatment of depression can help improve the overall quality of life for individuals with pancreatic cancer and may also improve outcomes related to the disease. Effective treatment of depression in individuals with pancreatic cancer may include a combination of therapy and medication. Therapy can help individuals cope with the emotional and psychological challenges of living with a serious illness and can provide support and guidance for managing the stress and emotional impact of cancer treatment. Medications, such as antidepressants, can also be effective in treating depression. In conclusion, pancreatic cancer is a serious and often deadly disease that is associated with an increased risk of depression. It is important for healthcare professionals to be aware of this association and to screen for depression in individuals with pancreatic cancer. Early detection and treatment of depression can help improve the overall quality of life for individuals with pancreatic cancer and may also improve outcomes related to the disease. Dr. A. Arrazaghi. MD,FRCPC